Vice President, Translational Data Science/Computational Biology

Company: Initial Therapeutics, Inc.
Location: Salt Lake City
Posted on: April 19, 2025

Job Description:

Your work will change lives. Including your own.Recursion's PlatformThe Recursion OS is our platform for the industrialization of drug discovery, linking digital and physical workflows to automate therapeutic program initiation and optimization in a scaled, data-driven manner. These workflows automatically validate biological insights from high-dimensional in vitro profiling and optimize chemical matter through loops of experimental data and ML predictions. They are powered by patient datasets and Recursion's "maps of biology" - a unique system integrating genome-scale reverse genetics and chemical profiling in a high-dimensional, uniform biological assay to predict trillions of relationships between biological perturbations and therapeutic candidates.As the Vice President of Computational Biology, you'll set the strategy and drive the implementation of connecting data from our genome-scale -omics platforms with population- and patient-derived genetics and leveraging advanced analytics including ML/data science to identify novel biological and chemical hypotheses and to validate those insights as they progress rapidly and efficiently through our drug development funnel. In this role, you will:

• Identify and set the strategy on technological and analytical advances in the computational biology field that will directly advance Recursion's portfolio and its mission to industrialize drug development
• Mentor teams to develop technologies to address specific questions that move multiple drug program and partnership projects forward
• Collaborate with Recursion's research-oriented teams to evaluate new technologies and decide on which to transition toward scaled production
• Lead the strategy and implementation efforts to identify optimal disease and patient linkages to our -omics phenotypes, along with the discovery and validation of translational biomarkers and patient selection solutions to drive precision medicine for our therapeutic programs
• Be a key member to contribute to the strategy for the collection of patient genetic and biomarker data in Recursion clinical trials for reverse translation
• Be a key member to contribute to strategy in support of the Recursion OS and clinical portfolio, building and nourishing strong links between computational biology and the larger cross-functional organization
• Collaborate with groups in discovery biology, chemistry, and data science to rapidly deliver a portfolio of therapeutic programs to the clinic
• Guide teams of computational biologists and data scientists in executing the above strategy to industrialize the process of turning maps into medicines
• Recruit, mentor, and manage high-performing teams of computational biologists and data scientists working in our therapeutic areas (oncology, neuroscience, and more) as well as on pan-therapeutic area initiatives, including genetics workSuccess in this role will be primarily defined by the impact you show on the industrialization of program initiation with translatable genetic/genomic insights, and of program progression to the development with defined, validated biomarker strategies in clinical development. Success will be defined by the delivery from and development of the therapeutic area computational teams reporting to you.The Team You'll JoinAs the VP, Translational Data Science/Computational Biology, you will report to the SVP Clinical Development & Data Science, joining a diverse leadership team spanning research, development, data science, machine learning, computational chemistry, and computational biology across Recursion. You will collaborate with peer leaders in data science, biology, chemistry, and engineering to drive both present execution and future industrialization in both Recursion's core therapeutic areas of oncology, neuroscience and future areas.The Experience You'll Need
  • 7+ years applying expertise in computational biology in service of advancing drug discovery and drug development programs. Particular consideration will be given to candidates with experience in oncology
  • Experience working in partnerships with both wet-lab and computational components
  • Demonstrated ability to manage multiple project teams with cross-functional delivery goals
  • A track record for pairing large-scale patient/population datasets in a closed loop with high-throughput in vitro functional genomics to transform the process of identifying targets, models, and biomarkers with patient connectivity and validity
  • Experience in developing and implementing patient stratification / precision medicine solutions in clinical development leveraging multi-omics and clinical data and well versed in regulatory considerations
  • Strong leadership of a multi-level management tree fostering an inclusive and diverse group with a passion for developing world-class talent in a matrixed environment
  • Curiosity and the professional skill-set to excel in an open, highly collaborative, and growth-oriented environmentLocation:This position is based in one of our offices located in Salt Lake City, New York City, Toronto or London. Please note that we are a hybrid environment and ask that employees spend 50% of their time in the office.How You'll be SupportedAt Recursion, we're working to solve some of the most meaningful challenges in human health. During onboarding, you'll be introduced to the Recursion Mindset and Recursion OS through a blend of in-person and online resources designed to help you quickly embrace our culture. You'll be paired with an onboarding "Trail Guide" to support you in your first months and connect with colleagues, both in person and remotely, who will guide you through the traditional and Recursion-specific aspects of your role. Additionally, you'll join onboarding events, like Decoding Recursion, to deepen your understanding and integration into the team.The Values That We Hope You Share:
    • We Care: We care about our drug candidates, our Recursionauts, their families, each other, our communities, the patients we aim to serve and their loved ones. We also care about our work.
    • We Learn: Learning from the diverse perspectives of our fellow Recursionauts, and from failure, is an essential part of how we make progress.
    • We Deliver: We are unapologetic that our expectations for delivery are extraordinarily high. There is urgency to our existence: we sprint at maximum engagement, making time and space to recover.
    • Act Boldly with Integrity: No company changes the world or reinvents an industry without being bold. It must be balanced; not by timidity, but by doing the right thing even when no one is looking.
    • We are One Recursion: We operate with a 'company first, team second' mentality. Our success comes from working as one interdisciplinary team.Recursion spends time and energy connecting every aspect of work to these values. They aren't static, but regularly discussed and questioned because we make decisions rooted in those values in our day-to-day work.More About RecursionRecursion is a clinical stage TechBio company leading the space by decoding biology to industrialize drug discovery. Enabling its mission is the Recursion OS, a platform built across diverse technologies that continuously expands one of the world's largest proprietary biological and chemical datasets. Recursion leverages sophisticated machine-learning algorithms to distill from its dataset a collection of trillions of searchable relationships across biology and chemistry unconstrained by human bias. By commanding massive experimental scale - up to millions of wet lab experiments weekly - and massive computational scale - owning and operating one of the most powerful supercomputers in the world, Recursion is uniting technology, biology and chemistry to advance the future of medicine.Recursion is headquartered in Salt Lake City, where it is a founding member of , the Utah life sciences industry collective. Recursion also has offices in London, Toronto, Montreal and the San Francisco Bay Area. Learn more at , or connect on (formerly Twitter) and .Recursion is an Equal Opportunity Employer that values diversity and inclusion. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected under applicable federal, state, local, or provincial human rights legislation. Recursion welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.
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